Embryo Biopsy for PGS/PGD

PGS (preimplantation genetic screening) refers to the examination of an IVF embryo’s overall chromosomal normality. It entails taking a biopsy of an IVF embryo and checking for a proper number of chromosomes before transferring the embryo. 

PGD (preimplantation genetic diagnosis) includes testing preimplantation stage embryos genetic for known genetic defects and excluding them. It is developed for couple with know history of same genetic defects before embryo transmission in the uterus.

The embryo biopsy procedure is used to determine the quality of an embryo and to look for chromosomal or genetic abnormalities. It’s usually done on those who are at a high risk of acquiring a chromosomal abnormality or a genetic illness. We can avoid transplanting genetically defective embryos by utilizing this method. 

The chromosome of embryos created by the IVF/ICSI for common anomalies is checked by PGS (sometimes referred to as aneuploidy screening). The primary reason for embryo implantation failure in IVF and abortions is chromosomal abnormalities. 

A genetic laboratory is in charge of these testing at SCI IVF Hospital.

The majority of patients are unsure in which conditions PGS is best. Before choosing genetic testing, we analyze each couple’s /history of families and recommend the best choice for them. However, your doctor may suggest PGS if:

• If the patient is over 35 years old and has a greater chance of having a child with a chromosomal abnormality (such as Down’s syndrome)
• Having a family history of chromosomal abnormalities
• Recurrent miscarriages/abortions in the past
• A patient has had numerous failed IVF rounds even though healthy embryos were transplanted
• Also, if sperm are known to be prone to chromosomal abnormalities 

Several studies, however, have cast doubt on whether PGS is truly beneficial in improving the odds of live delivery.

If you have any of the following symptoms, your doctor may prescribe PGD therapy to you:

• Because of a significant genetic issue, you’ve had to terminate prior pregnancies
• You already have a child that suffers from a significant genetic disorder
• You have a history of a serious genetic condition in your family
• You have chromosomal issues, which is a hereditary condition

IVF PGD and IVF PGS are generally conducted on embryos that are still in the developing phases, thus the embryo biopsy techniques change appropriately. In clinical practice, there are two types of biopsy:

• Trophoectoderm Biopsy – Four or five cells from the trophectoderm layer are removed from blastocyst stage embryos on day five, ensuring that there is no influence on the inner cell mass where the fetus develops.
• Blastomere Biopsy – One or two cells from eight-cell embryos are extracted on day
  three at the cleavage stage for genetic investigation.

The embryo biopsy cost India is highly affordable, and the patient receives all therapy and the entire facility. Even the finest surgeon and the finest hospital will treat the patient. This all attracts most patients into India and the best therapy, as it is quite difficult to figure out the best doctor and the fertility clinic in your native nation initially. 

It is ensured that you receive the most effective therapy and technique to address the problem of infertility at SCI IVF Hospital.

To present, investigations have shown that biopsies done by skilled embryologists at the blastocyst stage have no detrimental impact on the embryo or its capacity to generate a successful pregnancy. Embryo biopsy and analysis are becoming a more common adjunct to IVF for all age groups at many clinics as a result of this, as well as the constantly dropping cost of analysis and the higher pregnancy rates with PGS.