Embryo Biopsy For PGS/PGD in Delhi
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At SCI IVF Hospital, Delhi, we realize how crucial it is to you that your future child should have as healthy as possible. PGS/PGD or the embryo biopsy is an intervention utilized before IVF begins so that genetic or chromosomal errors in the embryos can be identified before they are transferred to the uterus. Also, Preimplantation Genetic Screening (PGS/PGT-A) and Preimplantation Genetic Diagnosis (PGD/PGT-M) are carried out by our specialists who selectively get rid of several cells located at the outside of a blastocyst (day 5 or 6 embryo) without affecting its further developmental process. This guarantees that selected embryos are healthy, thus increasing the probability of a healthy pregnancy and low chances of the child developing inherited disorders.
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What is Embryo Biopsy?
Embryo biopsy is a sensitive procedure that is done during the IVF process in which some cells are carefully taken out of the embryo- normally the day 5 or 6, known as the blastocyst stage of development. These embryos are not destroyed, because the sampling actually occurs on the trophectoderm (the cells that will form the placenta), not the inner cell mass (that grows into a baby).
This allows two ways:
PGS (Preimplantation Genetic Screening), now called PGT-A, tests whether there are the correct amount of chromosomes (46) - whether embryos are euploid rather than aneuploid
PGD (Preimplantation Genetic Diagnosis) is now PGT-M, which selects against a known single-gene cause and includes cystic fibrosis, Tay-Sachs (A Pro/Con Statement).
Both may be combined (PGT-A + PGT-M) in a single cycle so that chromosomal health, along with the absence of targeted genetic conditions, can be assured.
Process Timeline: Embryo Biopsy
- IVF To Blastocyst
Egg harvest, sperm inseminate and cultivate embryos up to day 56 blastocysts stage
- Biopsy Procedure
Cut off some of the trophectoderm cell with micro instruments or laser beam. The embryo is immune; it is subsequently cryopreserved
- Genetic Analysis
To identify chromosomal or gene-level abnormalities, cells are tested-through NGS, PCR, FISH, or array-based methods.
- Transfer Planning & Selection
Embryos that are deemed chromosomally and/or genetically most suitable are available in the future to be transferred; the others are stored in frozen or discarded
Benefits of Embryo Biopsy for PGS/PGD Treatment
The best candidates should be:
- Women over 35 where there are increased risks of erring in chromosomes during embryos.
- Couples who suffer recurrent fertilization or experience repeated miscarriages.
- Individuals who have a documented record of a family based disorder.
- Guys with pronounced harm to sperm and that can bring about karyotypic problems.
Risks of Embryo Biopsy for PGS/PGD
- Safety: It is overall safe with some chances of the arresting embryos, or their damage, particularly when thawing embryos after biopsy
- Possible limitations: PGT does not eliminate each of the risks of becoming pregnant- misdiagnosis, embryo mosaicism, and impeded detection ability are some of the possibilities
- Ethical Boundaries: In India, sex selection to purely non-medical purposes is not legal-use of PGD can only be used to avoid severe genetic disease.
Quick Wrapped Summary
Why Choose Us: SCI IVF Hospital
- More than 15 years of experience in high-tech procedures of IVF and genetic examination.
- Ultramodern laboratory equipped with all the new technologies of embryo biopsies and genetic analysis.
- Well experienced embryology unit which is educated based on international standards.
- Individual care and treatment according to your fertility and medical history.
- Tested success rates of thousands of successful healthy births.
FAQs on Embryo Biopsy For PGS/PGD
Yes. But when it is done by competent embryologists, not many cells of the outer layer are removed but the embryo is left in other normal ways.
This cannot be tested, but it is highly possible to minimize the possibility of genetic disorders and make the pregnancy successful.
Quite on the contrary, implantations rates may be enhanced by choosing chromosomally normal embryos and decrease the risk of miscarriage.
Genetic analysis is usually not quick and normally occupies 1-2 weeks. Embryos are biopsied and frozen to be transferred at a later cycle.
Yes, but only when there is medically valid reason to so, like to avoid severe genetic disorders, but not to select gender.
